For 1099 contractors & freelancers
Yes, travel away from home overnight for business is deductible, including flights, hotels, and 50% of meals.
Schedule C, line 24a (Travel), with meals on line 24b at 50%.
You must be away from your tax home (the area of your main place of business) longer than a normal workday, needing sleep or rest, for business reasons.
For a trip that mixes business and vacation in the U.S., airfare is deductible if the trip is primarily for business, and lodging and meals only for the business days.
Local rides to client meetings in your own city count as local transportation, not travel.
Receipts and the business purpose of each trip and day.
In Smart Deductions, this is suggested as Travel (Schedule C line 24a). You confirm it before it counts.
Sources
General information, not tax advice. For your specific situation, check with a CPA or Enrolled Agent.